Fungal Infections of the Lung

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Fungal infections of lung cause destructive inflammation.

Fungal infections of the lung are seen in two populations: most are seen in immunosuppressed patients, but rare cases occur in otherwise healthy patients by exposure to a specific agent indigenous to a particular geographic area.

Aspergillus infection of the lung can cause several patterns of disease, including a pneumonia which leads to extensive necrosis and infarction of affected lung because of vessel wall invasion by the fungus.

Histoplasmosis, coccidioidomycosis and sporotrichosis all cause chronic granulomatous inflammation of the lung, with fibrosis in a pattern resembling TB.

Cryptococcal pneumonia is mainly seen in immunocompromised patients.
It causes granulomatous inflammation, with consolidation and cavitation of lung.
Candida pneumonia is seen in severely debilitated patients and causes severe acute inflammation,
leading to a bronchopneumonic pattern of disease.
Aspergillus invades widely in lung, frequently involving vessel walls.
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