Islet Cell Tumor
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Most of the endocrine tissue in the pancreas
is located in discrete islands.
Islands of endocrine cells, the islets of Langerhans, are scattered throughout
The endocrine cells secrete:
• Pancreatic polypeptide.
• Amylin (IAPP).
The only other important condition after diabetus resulting from abnormality in
the endocrine component of
the pancreas is islet-cell tumour.
Tumours of the islet cells of the pancreas are examples of neuroendocrine
Most are benign, producing their symptoms through excess secretion of a specific
usually insulin. The tumours are usually solitary, but in the MEN syndromes most
Insulinoma produces hypersecretion of insulin, leading to hypoglycaemic attacks
that are often
severe enough to produce coma; pre-coma symptoms include confusion and
Glucagonoma is very rare. The excess secretion of glucagon is often
patients may be anaemic and develop an unexplained secondary diabetes. A bizarre
skin rash called necrolytic migratory erythema sometimes occurs.
Very rarely, islet-cell tumours may secrete unusual hormones such as vasoactive
peptide (VIP) and gastrin (producing the Zollinger-Ellison syndrome of recurrent
multiple peptic ulcers in stomach and proximal small intestine), or may even
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We give here simplified and accurate information about the disease
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