Myasthenia Gravis

Back to Library

Myasthenia gravis is an autoimmune disease caused by antibodies to the acetylcholine receptor

Myasthenia gravis is a disease characterized by fatigue weakness, ptosis and dysphagia.

A main differential diagnosis is with an inflammatory myopathy, which can have identical clinical features.
It is an autoimmune disease caused by generation of autoantibodies to the acetylcholine receptor located in the post-synaptic membrane of muscle motor end-plates. These antibodies prevent synaptic transmission by blocking the receptor sites.

Diagnosis can be made by giving a therapeutic trial of a short-acting anti-cholinesterase drug, which increases acetylcholine concentrations in the synaptic cleft and allows transmission. 

An important association with this condition is pathology of the thymus gland. About 25% of cases have a thymoma, others having thymic gland hyperplasia. Thymectomy may improve the myasthenia in a proportion of cases.

There is no diagnostic pathology seen by routine light microscopy in muscle biopsy.

Normally, acetyl choline is released from the axon terminal, diffuses into the space of the motor end plate and binds to acetyl choline receptors, causing muscle contraction.

In myaesthenia gravis antibodies to the receptor bind and prevent acetylcholine from activating muscle contraction.
Interested in translating health topics to somali language!

We give here simplified and accurate information about the disease Info@somalidoc.com


DISCLAIMER: This website is provided for general information and it's run by medical students for medical students only and is not a substitute for professional medical advice. We are not responsible or liable for any diagnosis or action made by a user based on the content of this website. We are not liable for the contents of any external websites listed, nor do we endorse any commercial product or service mentioned or advised on any of the sites. Always consult your own doctor if you are in any way concerned about your health

Advertising | Conditions of use | Privacy policy | Webmaster
Copyright 2007 [
www.somalidoc.com]. All rights reserved.
Revised: 02-11-2014.