Author Topic: How are Progeria and ageing similar?  (Read 4323 times)

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Offline dr-awale

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How are Progeria and ageing similar?
« on: May 13, 2009, 09:25:48 PM »
Children who suffer from Progeria are genetically susceptible to premature, progressive heart disease. Nearly all Progeria patients die from heart disease. Heart disease is also one of the leading causes of death globally. Children with Progeria commonly experience cardiovascular events, such as hypertension (high blood pressure), stroke, angina, enlarged heart and heart failure - conditions linked to aging.

Experts say that any research into finding a cure for Progeria would probably have results which would benefit adults with diseases linked to aging.


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How are Progeria and ageing similar?
« on: May 13, 2009, 09:25:48 PM »

Offline Sherloklewis

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Re: How are Progeria and ageing similar?
« Reply #1 on: June 09, 2010, 01:33:03 PM »
Hutchinson-Gilford Progeria Syndrome ("Progeria", or "HGPS") is a rare, fatal genetic condition characterized by an appearance of accelerated aging in children. Its name is derived from the Greek and means "prematurely old." Nuclear DNA repair mutants exhibit progeroid symptoms. There are many types of DNA damage, and, accordingly, we have evolved mechanisms to deal with each type of damage. Nucleotide excision repair removes bulky adducts, and base excision repair removes damaged bases. Mismatch repair fixes nucleotides that aren’t matched in their correct A:T/G:C configuration. Lastly, non-homologous end joining and recombination can fix double stranded breaks. Deficiencies in several of these repair mechanisms have been implicated in aging, and they may play a role in age-related disease.
Children with progeria, also known as Hutchinson-Gilford progeria syndrome (HGPS), generally appear normal at birth. By 12 months, signs and symptoms, such as skin changes and hair loss, begin to appear. The average life expectancy for a child with progeria is 13, but some with the disease die younger and some live 20 years or longer. Heart problems or stroke is the eventual cause of death in most children with progeria. There's no cure for this condition, but ongoing research shows some promise for treatment.

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Re: How are Progeria and ageing similar?
« Reply #1 on: June 09, 2010, 01:33:03 PM »

 

Progeria

Started by YaxyaBoard Cudurrada Caruurta

Replies: 8
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Last post June 09, 2010, 01:41:42 PM
by Sherloklewis