Definition of Neutropenia
Neutropenia: Not enough neutrophils, neutrophils being a type of white blood cell (specifically a form of granulocyte) filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed by phagocytosis. The mature neutrophil has a segmented nucleus (it is called a seg or poly) while the immature neutrophil has band-shape nucleus (it is called a band). The neutrophil has a lifespan of about 3 days.
Decreased production.
1-Infections.
•Tuberculosis.
•Mononucleosis.
•Hematologic disease
•Malaria
•Brucellosis
•Viral hepatitis
2-Malignancy.
3-Drugs.
4-Nutritional deficiencies
•Vitamin B12 deficiency.
•Folate deficiency
•Copper deficiency
5-Hematologic disease.
•Aplastic anemia
•Leukemia
•Cyclic neutropenia
•Myelodysplastic syndromes
•Chediak-Higashi syndrome
Increased destruction.
1-Autoimmune disorders.
•Felty’s syndrome
•SLE
2- Antineutrophil antibodies
3- Splenic sequestration
Peripheral marginations.
1-Sepsis.
2- Histoplasmosis.
