Micro & Immunity ... علم البكتيريا و الفيروسات & المناعة
Steps of Control of outbreak of an infectious disease
2I
Investigation .. to trace the source of the infection
Immunization activities
Non-Hepatotropic viruses
2V , 2c
Varicella
Viral hemorrhagic fevers
CMV .. cytomegalovirus
Coxsackie
ENDOTOXIN
Endothelial cells/ Edema
Negative .. gram- bacteria
DIC/ Death
Outer membrane
TNF
O-antigen
X-tremely heat stable
IL-1
Nitric oxide/ Neutrophil chemotaxis
Acute post-streptococcal glomerulonephritis: classic presentation
"Sore throat, Face bloat, Pi$$ coke"
Sore throat: 1 week ago
Face bloat: facial edema
Pi$$ coke: coke-coloured urine
Alternatively, short version: Throat, bloat and coke
Staphylococcus aureus: diseases caused
SOFT PAINS
Skin infections
Osteomyelitis
Food poisoning
Toxic shock syndrome
Pneumonia
Acute endocarditis
Infective arthritis
Necrotizing fasciitis
Sepsis
Food poisoning: bugs inducing
"Eating Contaminated Stuff Causes Very Big Smelly Vomit"
E. coli O157-H7 > under*****d meat, esp. hamburgers
Clostridium botulinum > canned foods
Salmonella > poultry, meat, eggs
Vibrio parahaemolyticus > seafood
Bacillus cereus > reheated rice
Staphylococcus aureus > meats, mayo, custard
Clostridium perfringens > reheated meat
Vibrio vulnificus > seafood
Streptococcus pyogenes: virulence factors
SMASHED
Streptolysins
M protein
Anti-C5a peptidase
Streptokinase
Hyaluronidase
Exotoxin
DNAses
Streptococcus pyogenes: diseases caused
NIPPLES
Necrotising fasciitis and myositis
Impetigo
Pharyngitis
Pneumonia
Lymphangitis
Erysipelas and cellulitis
Scarlet fever/ Streptococcal TSS
Endocarditis: lab results suggesting it
"High Tech Lab Results Point At Endocarditis"
Hematuria
Thrombocytopenia
Leukocytosis, -penia
Red blood cell casta
Proteinuria
Anemia
Elevated ESR
cepholosporins
CEPHALOSPORINS-tough but important
schedule of parents
1 pm:take a ZOLI(bag) and roam with a THIN FELLOW
2 pm:start ROXI video and watch TINTIN
3 pm:take a TAXI go to ZOne.where they meet one ZIDI boy who has worn PER AXONS slippers
4 pm:to cure PIMPLES they go to ROME
schedule of ORACLE
1 pm:go to DR.ALEX REDI's house
2 pm:because of aCHLORhydria he starts watching ROXI video and watch AXN
3 pmIN FIXes PROduction of BUTEN
now what is this >>
parents means parental root
1st generation cephalosporins:cePHALOTHIN,cefaZOLIN
2nd generation:cefuROXIME,cefoxiTIN
3rd generation:cefoTAXIme,ceftiZOxime,ceftaZIDIme,ceft riAXONE,cefoPERazone
4th:cefePIME,cefpiROM
ORACLE means oral root
1st gen:cefaDRoxil,cephALEXIN,cephRADIne
2nd gen:cefACHLOR,cefuROXIme AXetil
3rd gen:cefDINir,ceFIXime,cefpodoxime PROxetil,ceftiBUTEN
Capsulated pathogenic organisms are
Some Killers Have Pretty Nice Capsules
S Streptococcus pneumoniae
K Klebsiella pneumoniae
H Haemophilus influenzae
P Pseudomonas aeruginosa
N Neisseria meningitidis
C Cryptococcus neoformans
Remeber... All bacilli are gram negative except > L.DATTA
L - Listeria
D - Diphtheria
A - Actinomycetes
T - Tetani Clostridium
T - TB Mycobatcterium
A - Anthrax bacillus
Hypersensitivity reactions: Gell and Goombs nomenclature
ACID
• From I to IV
Anaphylactic type: type I
Cytotoxic type: type II
Immune complex disease: type III
Delayed hypersensitivity (cell mediated): type IV
MHC I vs. II: T cell interaction
The "=8" equation
2x4=8, and 1x8=8
MHC II goes with CD4
MHC I goes with CD8
Immunoglobulin (Ig) types: the important ones worth remembering, in order of appearance
MAGDElaine .. a girl's ****
IgM
IgA
IgG
IgD
IgE
• Magdelaine tells you the order they usually appear: M first, then A or G
• Alternatively: IgM is IMmediate
Acute inflammation features
SLIPR
Swelling
Loss of function
Increased heat
Pain
Redness
• "What a cute pair of slippers" can be used to tie acute inflammation to SLIPR
Lupus signs and symptoms
SOAP BRAIN
Serositis .. pleuritis, pericarditis
Oral ulcers
Arthritis
P***osensitivity
Blood .. all are low - anemia, leukopenia, thrombocytopenia
Renal .. protein
ANA
Immunologic .. DS DNA, etc
Neurologic .. psych, seizures
Goodpasture's Syndrome components
GoodPasture is Glomerulonephritis and Pnuemonitits
• From autoantibodies attacking Glomerular and Pulmonary basement membranes
Complement: function of C3a versus C3b
C3a: Activates Acute .. inflammation
C3b: Bonds Bacteria .. to macrophages--easier digestion
• If wish to know more than just C3
C3a, C4a, C5a activate acute
C3b, C4b bind bacteria
MHC I vs. MHC II properties
"Immunity helps to exterminate fun for bacteria"
HLA-DR genetic predisposition immune disease examples
HLA-DR
Hashimoto's disease
Leukemia/ Lupus
Autoimmune adrenalitis/ Anemia .. pernicious
Diabetes insipidous
Rheumatoid arthritis
Complement cascade initiating items: alternative vs. classic
Classic: Combined Complexes
Alternative: Activators Alone, or IgA
• Complexes are made of Ab and Ag combined together
• Examples of activators: endotoxin, microbial surface [/b]
Pathology .. علم دراســة الأمراض
MI: post-MI complications
ACT RAPID
Arrhythmias
Congestive cardiac failure
Tamponade/ Thromboembolic disorders
Rupture > septum, papillary muscle
Aneurysm
Pericarditis
Infaction > second one
Death/ Dressler's syndrome
Deep venous thrombosis: diagnosis
DVT
Dilated superficial veins/ Discoloration/ Doppler ultrasound
Venography is gold standard
Tenderness of Thigh and calf
MI: complications
HAS CRAPPED
Heart failure/ Hypertension
Arrhythmia
Shock
Cardiac Rupture
Aneurysm
Pericarditis
Pulmonary Emboli
DVT
Heart failure causes
"HEART MAy DIE"
Hypertension
Embolism
Anemia
Rheumatic heart disease
Thyrotoxicosis > in pregnancy
Myocardial infarct
Arrythmia
Y
Diet & lifestyle
Infection
Endocarditis
Cardiovascular risk factors
Framingham
FRAMINGHAM
Family history
Running
Adiposity
Marlboros
Insulin resistance
Non-regulated lipids
Georgie Pie
Hypertension
Age
Male
Multiple Endocrine Neoplasia (MEN) subtype classification
Each subtype has 2 or 3 causes, plus something 1 or 2 more items
MEN I is disease of 3 P's: [Pituitary, Parathyroid, Pancreas] plus one more: adrenal cortex
MEN II is disease of 2 C's: [Carcinoma of thyroid, Catacholamines (pheochromocytoma)] plus two more: parathyroid for MEN IIa or mucocutaneous neuromas for MEN IIB
also called MEN III
Takayasu's disease is Pulseless disease
Can't Tak'a ya pulse
Can't take your pulse
Takayasu's disease known as Pulseless disease, since pulse is weakened in the upper extremities
Hypercalcemia: symptoms of elevated serum levels
"Bones, Stones, Groans, Moans"
Bones: pain in bones
Stones: renal
Groans: pain
Psychic moans/ Psychological overtones: confused state
Acute ischemia: signs
6 P's
Pain
Pallor
Pulselessness
Paralysis
Paraesthesia
Perishingly cold
Hodgkin's lymphoma classification
A: Asymptomatic
B: Bad
Lichen planus characteristics
Planus has 4 P's
Peripheral
Polygonal
Pruritus
Purple
Hypertension: secondary hypertension causes
CHAPS
Cushing's syndrome
Hyperaldosteronism
Aorta coarctation
Phaeochromocytoma
Stenosis of renal arteries
• Note: only 5% of hypertension cases are secondary, rest are primary
Hepatomegaly: 3 common causes, 3 rarer causes
Common are 3 C's
Cirrhosis
Carcinoma
Cardiac failure
Rarer are 3 C's
Cholestasis
Cysts
Cellular infiltration
MI: sequence of elevated enzymes after MI
C-AST-Le
castle
CK-MB first
AST second
LDH third
• Also: can use the last 'E' for ESR
Pulmonary embolism: risk factors
TOM SCHREPFER
Trauma
Obesity
Malignancy
Surgery
Cardiac disease
Hospitalization
Rest
Elderly
Past history
Fracture
Estrogen
Road tripa
Toxicology & Pharmacology .. الســــموم & الأدوية
Factors affecting the action of poisons
DRS درس
Dose
Route of administration
State
Drugs cause tachycardia
CASH كاش
Cocaine
Atropine
Amphetamine
Salicylate
Hashish
Drugs cause Bradycardia
SODA صودا
Sedative & hypnotics
Opiate
Digitalis
Anticholinestrase
Poisons cause hypertension
MCAN مكان
Morphine withdrawal
Cocaine
Amphetamine
Nicotine
Poisons cause Pupillary dilatation2A , 2C , 2M
Atropine
Amphetamine
Cocaine
CO
Menthol
Morphine withdrawal
Poisons cause optic neuritis
NML نمل
Naphthalene
Methanol
Lead
Poisons decrease salivation
MAN
Morphine
Atropine
Nutmeg
Hepatotoxic drugs
HEPATIC
Hemolytic poisons
Ethanol
Paracetamol
Aflatoxin
Toxaphene
Iron
Chlorpromazine
Nephrotoxic drugs
NEPHRO
NSAIDS
Ergot alkaloids
Pre renal failure
Heavy ****ls
Rhabdomylosis causing drugs
Oxalic acid
Drugs causing ****bolic acidosis
TSLIM تســليم
TCA
Salicylate
Lethium
Iron
Methanol
Poisons acting on Cerebral Cortex in ttt of convulsion
2A , 2C
Atropine
Amphetamine
Cocaine
Caffine
First-aid Treatment of poisoning
A B C D
Airway >> Suction of secretion
Breathing >> Oxygen via endotracheal tube
Circulation >> I.V. injections
Disability >> Convulsions & Coma
Symptomatic ttt of poisoning coma
A B C D E F
Antibiotics … to avoid infection
Bowel care … by enema
Bladder care … by catheterization
Buccal care … by frequent washing
Blanket … to warm the patient
Bed sores … change the position of the patient
Continuous monitoring of pulse , B.P. , temp and reflexes
Dehydration … ttt by I.V. fluids
Electrolytes
Fluid balance
Feeding … by ryle tube & I.V. fluids
Naloxone … 4 respiratory depression >> 2mg i.v
Succinylcholine: action, use
Succinylcholine gets Stuck to Ach receptor, then Sucks ions in through open pore
You Suck stuff in through a mouth-tube, and drug is used for intubation
Cholinergics (eg organophosphates): effects
If you know these, you will be LESS DUMB
Lacrimation
Excitation of nicotinic synapses
Salivation
Sweating
Diarrhea
Urination
Micturition
Bronchoconstriction
Steroids: side effects
BECLOMETHASONE
Buffalo hump
Easy bruising
Cataracts
Larger appetite
Obesity
Moonface
Euphoria
Thin arms & legs
Hypertension/ Hyperglycaemia
Avascular necrosis of femoral head
Skin thinning
Osteoporosis
Negative nitrogen balance
Emotional liability
Methyldopa: side effectsMETHYLDOPA
Mental retardation
Electrolyte imbalance
Tolerance
Headache/ Hepatotoxicity
psYcological upset
Lactation in female
Dry mouth
Oedema
Parkinsonism
Anaemia
Sodium valproate: side effects
VALPROATE
Vomiting
Alopecia
Liver toxicity
Pancreatitis/ Pancytopenia
Retention of fats
Oedema
Appetite increase
Tremor
Enzyme inducer
Captopril (an ACE inhibitor): side effects
CAPTOPRIL
Cough
Angioedema/ Agranulocystosis
Proteinuria/ Potassium excess
Taste changes
Orthostatic hypotension
Pregnancy contraindication/ Pancreatitis/ Pressure drop
Renal failure (and renal artery stenosis contraindication)/ Rash
Indomethacin inhibition
Leukopenia/ Liver toxicity
Lithium: side effects
LITH
Leukocytosis
Insipidus [diabetes insipidus, tied to polyuria]
Tremor/ Teratogenesis
Hypothyroidism
Opioids: effects
BAD AMERICANS
Bradycardia & hypotension
Anorexia
Diminished pupilary size
Analgesics
Miosis
Euphoria
Respiratory depression
Increased smooth muscle activity
Constipation
Ameliorate cough reflex
Nausea and vomiting
Sedations
Ca++ channel blockers: uses
CA++ MASH
Cerebral vasospasm/ CHF
Angina
Migranes
Atrial flutter, fibrillation
Supraventricular tachycardia
Hypertension
Alternatively >
CHASM
Cererbral vasospasm / CHF
Hypertension
Angina
Suprventricular tachyarrhythmia
Migranes
HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactionsHMG-CoA
• Side effects
Hepatotoxicity
Myositis
• Contraindications
Girl during pregnancy/ Growing children
• Interactions
Coumarin/ Cyclosporine
Antiarrhythmics: class III members
BIAS
Bretylium
Ibutilide
Amiodarone
Sotalol
Beta-blockers: main contraindications, cautions
ABCDE
Asthma
Block>heart block
COPD
Diabetes mellitus
Electrolyte>hyperkalemia
Clopidogrel: use
CLOPIdogrel is a drug that prevents
CLots, an Oral Platelet Inhibitor>OPI
Amiodarone: action, side effects
6 P's
Prolongs action potential duration
P***osensitivity
Pigmentation of skin
Peripheral neuropathy
Pulmonary alveolitis and fibrosis
Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism
Beta blockers: members
"The NEPALPrime Minister"
Timolol
Nadolol
Esmolol
Pindolol
Atenolol
Labetalol
Propranolol
Metoprolol
Beta-blockers: nonselective beta-blockers
"Tim Pinches His Nasal Problem>because he has a runny nose
Timolol
Pindolol
Hismolol
Naldolol
Propranolol
Antiarrhythmics: classification I to IV
MBACollege• In order of class I to IV
Membrane stabilizers>class I
Beta blockers
Action potential widening agents
Calcium channel blockers
Enoxaprin (prototype low molecular weight heparin): action, monitoring
EnoXaprin only acts on factor Xa
Monitor Xa concentration, rather than APTT
PREANASTHETIC MEDICATION
HOSANA this is a christian word
H-H2blockers
O-opeoids
S-sedatives-antianxiety
A-anticholenergic
N-neuroleptics
A-antiemetics
anti epeleptic drugs
Dr.BHAISAB's New PC
D...deoxy barbiturates
B...barbiturates
H....hydantoin
A.. aliphatic carb acids
I....iminostilbenes
S....succinimides
B....BZD's
N.... newer drugs
P....Phenyltriazines
C... cyclic gaba analogues
adverse effects of tetracyclins
KAPIL DEV
K kidney toxicity
A antianabolic effect
P p***otoxicity
I inc ICP
L liver toxicity
D diabetes insipidus
E e****l problems
V vestibular toxicity
GENERAL TOXICITY OF ANTICANCER DRUGS
SHaLi's BFGhoghari Gautam is Chor
S-skin
H-hyperurecemia
L-lymphoreticular tissue
B-bone marrow
F-Foetus
G-gonads
G-git
C-carcinogenecity
inhalational corticosteroids
Bed Bug Flew To Florida
B-BECLOMETHASONE DIPROPIONATE
B-BUDESONIDE
F-FLUTICASONE PROPIONATE
T-TRIAMCINALONE
F-FLUNISOLIDE
ENT .. أنف و أذن و حنجرة
Nasopharyngeal carcinoma: classic symptoms
NOSE
Neck mass
Obstructed nasal passage
Serous otitis media externa
Epistaxis or discharge
Ear drops: direction to pull ear when instilling
For an grown UP it is UP
For a chilD it is Down
Oralpharangeal cancers: aetiology
6 S's
Smoking
Spicy food
Syphilis
Spirits .. booze
Sore tooth
Sepsis
Ophthalmolgy .. الرمـــد
Hereditary diseases which lead to cataract
4M
Mongolism
Myotonic dystrophy
Marfan`s syndrome
Marchesani`s syndrome
Symplepharon . . . clinical picture
3D
Disfigurement & lagophthaloms
Diplopia
Diminution of vision
Optic atrophy causes
ICING
Ischaemia
Compressed nerve
Intracranial pressure > raised
Neuritis history
Glaucoma
Red eye causes
GO SUCK
Glaucoma
Orbital disease
Scleritis
Uveitis
Conjunctivitis
Keratitis
Anopsia: quarantic anopsia: location of lesion
Upper: Top: Temporal lesions
Lower: Pits: Parietal lesions
Cataracts: causes
ABCDE
Aging
Bang: trauma, other injuries .. eg infrared
Congenital
Diabetes and other ****bolic disturbances
Eye diseases: glaucoma, uveitis
Diplopia (uniocular): causes
ABCD
Astigmatism
Behavioral: psychogenic
Cataract
Dislocated lens
Corneal stromal dystrophies
"Marilyn Monroe Gets High in LA"
Macular: Mucopolysaccharide
Granular: Hyaline
Lattice: Amyloid
Nasopharyngeal cancer: classic symptoms
NOSE
Neck mass
Obstructed nasal passage
Serous otitis media externa
Epistaxis and discharge
Cataracts: differential
CATARAct
Congenital
Aging
Toxicity
Accidents
Radiation
Abnormal ****bolism
Dacryocystitis, dacryoadenitis: apparatus affected
Dacryocystitis, dacryadenitis
• Cry, so affects lacrimal gland
• Infection and inflammation, respectively
Cataracts: causes
CATARAct
Congenital
Aging
Toxicity
Accidents
Radiation
Abnormal ****bolism